The actress starred in Golden Egg in 2013, which also featured Justus Esiri.

Though in 2015 during an nterview, she revealed that Duplex was the most challenging role she has played. Speaking about what she can't do in a film, Okpoko has also featured in several Nigerian television series including Dear Mother, Clinic Matters, Neta, University Mafias, Sorrowful Child, Sacrifice the Baby, Red Scorpion, and Baby Oku. In 2015, she acted alongside Majid Michel and Beverly Naya in The Madman I Love.

Okpoko was also one of the cast members in Uche Jombo's Good Home (2016), which featured Okey Uzoeshi and Seun Akindele. The film plot addressed human trafficking from the Nigerian perspective.

The actress is currently blind and need urgent medical help.